H.pylori infection in patients with gastrointestinal symptoms Gastric or duodenal biopsy followed by urease testing (presumptive), culture, and/or histological staining are examples of specimen-dependent and costly invasive diagnostic methods. The urea breath test is one example of a non-invasive technique. The H.pylori Antibody Test is a simple test that uses a combination of H.pylori antigen coated particles and anti-human IgG to detect H.pylori antibodies in whole blood, serum, or plasma in a quantitative and selective manner.